Structure and mechanism of lanthipeptide biosynthetic enzymes

Research output: Contribution to journalReview articlepeer-review


Lanthipeptides are members of the ribosomally synthesized and post-translationally modified peptide (RiPP) natural products. They contain thioether crosslinks generated by dehydration of Ser and Thr residues followed by the addition of the thiol of Cys residues to the dehydroamino acids. Recent studies have revealed unexpected mechanisms of the post-translational modifications, and structural studies have started to provide insights into recognition of the peptide substrates by the modification enzymes.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalCurrent Opinion in Structural Biology
StatePublished - Dec 1 2014

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology


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