Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin

Research output: Contribution to journalReview article

Abstract

Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalArchives of Biochemistry and Biophysics
Volume505
Issue number1
DOIs
StatePublished - Jan 1 2011

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Fosfomycin
Organophosphonates
Biosynthesis
Enzymes
Proteins
phosphinothricin

Keywords

  • Antibiotics
  • Dioxygenase
  • Epoxidase
  • Methyl transferase
  • Phosphonates
  • Resistance
  • X-ray crystallography

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

Cite this

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abstract = "Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.",
keywords = "Antibiotics, Dioxygenase, Epoxidase, Methyl transferase, Phosphonates, Resistance, X-ray crystallography",
author = "Nair, {Satish K} and {van der Donk}, {Wilfred Adrianus}",
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AB - Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.

KW - Antibiotics

KW - Dioxygenase

KW - Epoxidase

KW - Methyl transferase

KW - Phosphonates

KW - Resistance

KW - X-ray crystallography

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