Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin

Satish K. Nair; Wilfred A. Van Der Donk

doi:10.1016/j.abb.2010.09.012

Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin

Research output: Contribution to journal › Review article › peer-review

Abstract

Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.

Original language	English (US)
Pages (from-to)	13-21
Number of pages	9
Journal	Archives of Biochemistry and Biophysics
Volume	505
Issue number	1
DOIs	https://doi.org/10.1016/j.abb.2010.09.012
State	Published - Jan 1 2011

Keywords

Antibiotics
Dioxygenase
Epoxidase
Methyl transferase
Phosphonates
Resistance
X-ray crystallography

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology

Online availability

10.1016/j.abb.2010.09.012

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title = "Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin",

abstract = "Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.",

keywords = "Antibiotics, Dioxygenase, Epoxidase, Methyl transferase, Phosphonates, Resistance, X-ray crystallography",

author = "Nair, {Satish K.} and {Van Der Donk}, {Wilfred A.}",

note = "Funding Information: This work has been supported by the National Institutes of Health ( PO1 GM077596 to W.A.V. and S.K.N.). We thank our collaborator Bill Metcalf and his laboratory for their contributions to the work described in this review.",

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N2 - Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.

AB - Recent years have seen a rapid increase in the mechanistic and structural information on enzymes that are involved in the biosynthesis and breakdown of naturally occurring phosphonates. This review focuses on these recent developments with an emphasis on those enzymes that have been characterized crystallographically in the past five years, including proteins involved in the biosynthesis of phosphinothricin, fosfomycin, and dehydrophos and proteins involved in resistance mechanisms.

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KW - Dioxygenase

KW - Epoxidase

KW - Methyl transferase

KW - Phosphonates

KW - Resistance

KW - X-ray crystallography

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Structure and mechanism of enzymes involved in biosynthesis and breakdown of the phosphonates fosfomycin, dehydrophos, and phosphinothricin

Abstract

Keywords

ASJC Scopus subject areas

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