Structural Dynamics and Processing of Nucleic Acids Revealed by Single-Molecule Spectroscopy

Taekjip Ha

Research output: Contribution to journalReview article


Single-molecule fluorescence spectroscopy is a powerful method to observe real time movements of individual biological molecules while they are functioning without the need for synchronization. Dynamic characteristics of nucleic acids can now be easily and reliably studied, and new applications are emerging in which their recognition and processing by proteins and enzymes are being understood with unprecedented detail. The most recent examples are discussed, including the hairpin ribozyme, Holliday junction, G-quadruplex, Rep helicase, reverse transcriptase, and combination with mechanical manipulation.

Original languageEnglish (US)
Pages (from-to)4055-4063
Number of pages9
Issue number14
StatePublished - Apr 13 2004


ASJC Scopus subject areas

  • Biochemistry

Cite this