Structural determinants of the mechanical stability of α-Catenin

Jing Li; Jillian Newhall; Noboru Ishiyama; Cara Gottardi; Mitsuhiko Ikura; Deborah E. Leckband; Emad Tajkhorshid

doi:10.1074/jbc.M115.647941

Structural determinants of the mechanical stability of α-Catenin

Jing Li, Jillian Newhall, Noboru Ishiyama, Cara Gottardi, Mitsuhiko Ikura, Deborah E. Leckband, Emad Tajkhorshid

Research output: Contribution to journal › Article › peer-review

Abstract

Background: We investigated how α-catenin transduces force at cell-to-cell adhesions. Results: Molecular dynamics simulations identified structural features contributing to α-catenin stability and its deformation under applied force. Conclusion: A cooperative network of salt bridges in α-catenin regulates both α-catenin stability and how it unfolds under force. Significance: These findings reveal the molecular basis of experimental observations and the impact of reported cancer-linked α-catenin mutants.

Original language	English (US)
Pages (from-to)	18890-18903
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	290
Issue number	31
DOIs	https://doi.org/10.1074/jbc.M115.647941
State	Published - Jul 31 2015

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

Online availability

10.1074/jbc.M115.647941

Library availability

Discover UIUC Full Text

Cite this

@article{d7724bcd34b14e0ea00bb3800a146cec,

title = "Structural determinants of the mechanical stability of α-Catenin",

abstract = "Background: We investigated how α-catenin transduces force at cell-to-cell adhesions. Results: Molecular dynamics simulations identified structural features contributing to α-catenin stability and its deformation under applied force. Conclusion: A cooperative network of salt bridges in α-catenin regulates both α-catenin stability and how it unfolds under force. Significance: These findings reveal the molecular basis of experimental observations and the impact of reported cancer-linked α-catenin mutants.",

author = "Jing Li and Jillian Newhall and Noboru Ishiyama and Cara Gottardi and Mitsuhiko Ikura and Leckband, {Deborah E.} and Emad Tajkhorshid",

note = "Publisher Copyright: {\textcopyright} 2015 by The American Society for Biochemistry and Molecular Biology, Inc.",

year = "2015",

month = jul,

day = "31",

doi = "10.1074/jbc.M115.647941",

language = "English (US)",

volume = "290",

pages = "18890--18903",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "31",

}

TY - JOUR

T1 - Structural determinants of the mechanical stability of α-Catenin

AU - Li, Jing

AU - Newhall, Jillian

AU - Ishiyama, Noboru

AU - Gottardi, Cara

AU - Ikura, Mitsuhiko

AU - Leckband, Deborah E.

AU - Tajkhorshid, Emad

PY - 2015/7/31

Y1 - 2015/7/31

N2 - Background: We investigated how α-catenin transduces force at cell-to-cell adhesions. Results: Molecular dynamics simulations identified structural features contributing to α-catenin stability and its deformation under applied force. Conclusion: A cooperative network of salt bridges in α-catenin regulates both α-catenin stability and how it unfolds under force. Significance: These findings reveal the molecular basis of experimental observations and the impact of reported cancer-linked α-catenin mutants.

AB - Background: We investigated how α-catenin transduces force at cell-to-cell adhesions. Results: Molecular dynamics simulations identified structural features contributing to α-catenin stability and its deformation under applied force. Conclusion: A cooperative network of salt bridges in α-catenin regulates both α-catenin stability and how it unfolds under force. Significance: These findings reveal the molecular basis of experimental observations and the impact of reported cancer-linked α-catenin mutants.

UR - http://www.scopus.com/inward/record.url?scp=84940492081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84940492081&partnerID=8YFLogxK

U2 - 10.1074/jbc.M115.647941

DO - 10.1074/jbc.M115.647941

M3 - Article

C2 - 26070562

AN - SCOPUS:84940492081

SN - 0021-9258

VL - 290

SP - 18890

EP - 18903

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 31

ER -

Structural determinants of the mechanical stability of α-Catenin

Abstract

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this