Abstract

Background: We investigated how α-catenin transduces force at cell-to-cell adhesions. Results: Molecular dynamics simulations identified structural features contributing to α-catenin stability and its deformation under applied force. Conclusion: A cooperative network of salt bridges in α-catenin regulates both α-catenin stability and how it unfolds under force. Significance: These findings reveal the molecular basis of experimental observations and the impact of reported cancer-linked α-catenin mutants.

Original languageEnglish (US)
Pages (from-to)18890-18903
Number of pages14
JournalJournal of Biological Chemistry
Volume290
Issue number31
DOIs
StatePublished - Jul 31 2015

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Catenins
Mechanical stability
Cell adhesion
Molecular Dynamics Simulation
Cell Adhesion
Molecular dynamics
Salts
Computer simulation
Neoplasms

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Structural determinants of the mechanical stability of α-Catenin. / Li, Jing; Newhall, Jillian; Ishiyama, Noboru; Gottardi, Cara; Ikura, Mitsuhiko; Leckband, Deborah E.; Tajkhorshid, Emad.

In: Journal of Biological Chemistry, Vol. 290, No. 31, 31.07.2015, p. 18890-18903.

Research output: Contribution to journalArticle

Li, Jing ; Newhall, Jillian ; Ishiyama, Noboru ; Gottardi, Cara ; Ikura, Mitsuhiko ; Leckband, Deborah E. ; Tajkhorshid, Emad. / Structural determinants of the mechanical stability of α-Catenin. In: Journal of Biological Chemistry. 2015 ; Vol. 290, No. 31. pp. 18890-18903.
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