Structural Consequences of Hydrophilic Amino Acid Substitutions in the Hydrophobic Pocket of Human Carbonic Anhydrase II

Keyphrases

• Side Chain 100%
• Amino Acid Substitution 100%
• Hydrophobic Pocket 100%
• Hydrophilic Amino Acid 100%
• Human Carbonic Anhydrase II 100%
• Substrate Associations 60%
• CO2 Hydrase 60%
• Carbonic Anhydrase 40%
• 3D Structure 20%
• Active Sites 20%
• X-ray Crystallography 20%
• Water Molecule 20%
• Hydroxide 20%
• Ca(II) 20%
• Zinc 20%
• Nucleophilic 20%
• Kcat 20%
• Aliphatic Side Chain 20%
• Catalytic Efficiency 20%
• Crystallographic Methods 20%
• Structure-activity Relationship 20%
• Hydrophobic-hydrophilic 20%
• CO2 Hydration 20%
• Hydrophobic Patch 20%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Amino Acid Substitution 100%
• Carbonic Anhydrase II 100%
• Human Carbonic Anhydrase II 100%
• Biochemistry 50%
• Structure Activity Relation 50%
• X Ray 50%
• Active Site 50%
• Enzyme 50%
• Turnover Number 50%
• Nucleophilicity 50%
• Catalytic Efficiency 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Amino Acid 100%
• Carbon Dioxide 100%
• Carbonate Dehydratase II 100%
• Arginine 40%
• Hydration 20%
• Structure Activity Relationship 20%