Professor Y.C. Fung has shown that living tissues remodel extensively in response to mechanical forces such as blood pressure variations. At the cellular level, those mechanical perturbations must be perceived by individual cells. However, mechanisms of mechanochemical transduction in living cells remain a central challenge to cell biologists. Contrary to predictions by existing models of living cells, we reported previously that a local stress, applied via integrin receptors, is propagated to remote sites in the cytoplasm and is concentrated at discrete foci. Here we report that these foci of strains and stresses in the cytoplasm correspond to local peak deformation or local buckling ofmicrotubules and are near the actin bundles of the cell. Multiple images at different z heights demonstratedmore foci of concentrated displacements in the middle of the cell than at the apex or at the cell base. Together with previously published work, these findings underscore the importance of tensed bundled filamentous actin in intracellularmechanical stress distribution and signaling.

Original languageEnglish (US)
Pages (from-to)33-44
Number of pages12
JournalMCB Molecular and Cellular Biomechanics
Issue number1
StatePublished - 2010


  • Actin bundles
  • Integrins
  • Mechanical deformation
  • Microtubules

ASJC Scopus subject areas

  • Cell Biology
  • Biophysics
  • Molecular Biology
  • Molecular Medicine


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