Structural Basis for Enzymatic Off-Loading of Hybrid Polyketides by Dieckmann Condensation

Keyphrases

• Hybrid Polyketide 100%
• Cyclase 100%
• Tetramate 100%
• Dieckmann Condensation 100%
• Mechanistic Insight 50%
• Head Group 50%
• Chemical Reaction 50%
• Substrate Recognition 50%
• Gene Cluster 50%
• Epoxides 50%
• Heterocycles 50%
• Bioinformatics 50%
• Nonribosomal Peptides 50%
• Profile Analysis 50%
• Pyridone 50%
• Heterocycle Synthesis 50%
• Structure-guided mutagenesis 50%
• Product Profile 50%
• Enzymology 50%
• Thioesterase 50%
• Cerulenin 50%
• Peptide Natural Products 50%
• Bioactive Natural Products 50%
• Covalent Complex 50%
• Nocamycins 50%
• Heterocyclization 50%

Biochemistry, Genetics and Molecular Biology

• Polyketide 100%
• Cyclase 100%
• Mutagenesis 50%
• Crystal Structure 50%
• Enzyme 50%
• Gene Cluster 50%
• Nonribosomal Peptide 50%
• Enzymology 50%
• Thioesterase 50%
• Bioinformatics 50%