Structural aspects of interactions within the Myc/Max/Mad network

S. K. Nair, S. K. Burley

Research output: Contribution to journalReview articlepeer-review


Recently determined structures of a number of Myc family proteins have provided significant insights into the molecular nature of complex assembly and DNA binding. These structures illuminate the details of specific interactions that govern the assembly of nucleoprotein complexes and, in doing so, raise more questions regarding Myc biology. In this review, we focus on the lessons provided by these structures toward understanding (1) interactions that govern transcriptional repression by Mad via the Sin3 pathway, (2) homodimerization of Max, (3) heterodimerizalion of Myc-Max and Mad-Max, and (4) DNA recognition by each of the Max-Max, Myc-Max, and Mad-Max dimers.

Original languageEnglish (US)
Pages (from-to)123-143
Number of pages21
JournalCurrent Topics in Microbiology and Immunology
StatePublished - 2006

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


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