Abstract
The genes coding for 20-kDa lymphotoxin (TNF-β) and tumor necrosis factor (TNF-α) have been cloned from a rabbit genomic library. The two genes are tandemly arranged and separated by only 1 kb of DNA, as previously observed in human and mouse genomes. We have sequenced the entire rabbit lymphotoxin-encoding gene and inferred the primary structure of rabbit TNF-β, whose cDNA is not yet cloned. We also analysed the upstream sequences of the rabbit TNF-β and TNF-α genes and identified a number of potential binding sites for known nuclear transcription factors, and in particular several putative κB-type sequences.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 215-221 |
| Number of pages | 7 |
| Journal | Gene |
| Volume | 95 |
| Issue number | 2 |
| DOIs | |
| State | Published - Nov 15 1990 |
| Externally published | Yes |
Keywords
- Recombinant DNA
- cytokines
- gene duplication
- transcription factors
- upstream regions
ASJC Scopus subject areas
- Genetics
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