Strictosidine synthase: Mechanism of a Pictet-Spengler catalyzing enzyme

Keyphrases

• Carboline 100%
• Strictosidine Synthase 100%
• Pictet-Spengler Reaction 100%
• Pictet-Spengler 100%
• Kinetic Isotope Effect 66%
• Rate-controlling 66%
• Rearomatization 66%
• Active Sites 33%
• Ab Initio Calculations 33%
• Positively Charged 33%
• Acid-catalyzed 33%
• Protonation 33%
• Aldehydes 33%
• PH Dependence 33%
• Aromatic Amines 33%
• Transition State 33%
• Diastereoselective 33%
• Biosynthetic Enzymes 33%
• Tetrahydroquinoline 33%
• Rate-controlling Step 33%
• Reaction Mechanism 33%
• Cyclization 33%
• Enzymatic Reaction 33%
• Carbinolamine 33%
• Detailed Mechanism 33%
• Stereoselective Synthesis 33%
• Enzyme Mechanism 33%
• Acid-base Catalysis 33%
• Alkaloid Synthesis 33%
• Enzymatic Catalysis 33%
• Solution Reaction 33%
• Plant Alkaloids 33%
• Bisubstrate Inhibitor 33%
• Spiroindolenine 33%
• Iminium Intermediates 33%

Biochemistry, Genetics and Molecular Biology

• Enzyme 100%
• Synthase 100%
• Pictet Spengler Reaction 60%
• Solution and Solubility 40%
• Kinetic Isotope Effect 40%
• Active Site 20%
• Protonation 20%
• Enzyme Mechanism 20%
• Alkaloids Biosynthesis 20%

Chemistry

• Pictet-Spengler Synthesis 100%
• Kinetic Isotope Effect 40%
• Rearomatization 40%
• Ab Initio Calculation 20%
• Transition State 20%
• Rate-Controlling Step 20%
• Enzymatic Reaction 20%
• Stereoselective Synthesis 20%
• Acid-Base Catalysis 20%
• Aromatic Amine 20%
• protonation 20%
• Aldehyde 20%