Streamlined Synthesis of PEG-Polypeptides Directly from Amino Acids

Tianrui Xue, Ziyuan Song, Yizhuo Wang, Boya Zhu, Zihao Zhao, Zhengzhong Tan, Xuefang Wang, Yingchun Xia, Jianjun Cheng

Research output: Contribution to journalArticlepeer-review


The application of synthetic polypeptides is greatly limited by the difficulty of the purification and polymerization of N-carboxyanhydrides (NCAs). Here, we report a streamlined, controlled synthesis of polypeptides directly from amino acids, avoiding the NCA purification, by adding small-molecular amine scavengers (AS) in situ to efficiently eliminate the remaining organic impurities in the emulsion polymerization system. Such a process enables controlled synthesis of PEG-containing, homo, block, and random polypeptides in a highly consistent manner under open-air condition, directly from amino acid derivatives in various formats and independent of NCA preparation methods.

Original languageEnglish (US)
Pages (from-to)6589-6597
Number of pages9
Issue number15
StatePublished - Aug 11 2020

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry


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