Stochastic chemical kinetics and the quasi-steady-state assumption: Application to the Gillespie algorithm

Christopher V. Rao, Adam P. Arkin

Research output: Contribution to journalArticlepeer-review

Abstract

The quasi-steady-state assumption (QSSA) is a powerful tool for simplifying the reaction kinetics, and it is successfully applied to numerous problems in deterministic kinetics. Thus, it is demonstrated how the QSSA may be applied to stochastic kinetics. It is emphasized that the same limitations of the QSSA in the deterministic case also hold in the stochastic framework.

Original languageEnglish (US)
Pages (from-to)4999-5010
Number of pages12
JournalJournal of Chemical Physics
Volume118
Issue number11
DOIs
StatePublished - Mar 15 2003
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy
  • Physical and Theoretical Chemistry

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