TY - JOUR
T1 - Stimulus-elicited connectivity influences resting-state connectivity years later in human development
T2 - A prospective study
AU - Gabard-Durnam, Laurel Joy
AU - Gee, Dylan Grace
AU - Goff, Bonnie
AU - Flannery, Jessica
AU - Telzer, Eva
AU - Humphreys, Kathryn Leigh
AU - Lumian, Daniel Stephen
AU - Fareri, Dominic Stephen
AU - Caldera, Christina
AU - Tottenham, Nim
N1 - Funding Information:
This work was supported by National Institute of Mental Health Grant R01MH091864 to N.T. and National Science Foundation Graduate Research Fellowship to L.J.G.-D. and D.G.G. The content is solely the responsibility of the authors and does not necessarily represent the views of the National Institute of Mental Health or the National Science Foundation.
Publisher Copyright:
© 2016 the authors.
PY - 2016/4/27
Y1 - 2016/4/27
N2 - Although the functional architecture of the brain is indexed by resting-state connectivity networks, little is currently known about the mechanisms through which these networks assemble into stable mature patterns. The current study posits and tests the long-term phasic molding hypothesis that resting-state networks are gradually shaped by recurring stimulus-elicited connectivity across development by examining how both stimulus-elicited and resting-state functional connections of the human brain emerge over development at the systems level. Using a sequential design following 4- to 18-year-olds over a 2 year period, we examined the predictive associations between stimulus-elicited and resting-state connectivity in amygdala-cortical circuitry as an exemplar case (given this network's protracted development across these ages). Age-related changes in amygdala functional connectivity converged on the same regions of medial prefrontal cortex (mPFC) and inferior frontal gyrus when elicited by emotional stimuli and when measured at rest. Consistent with the long-term phasic molding hypothesis, prospective analyses for both connections showed that the magnitude of an individual's stimulus-elicited connectivity unidirectionally predicted resting-state functional connectivity 2 years later. For the amygdala-mPFC connection, only stimulus-elicited connectivity during childhood and the transition to adolescence shaped future resting-state connectivity, consistent with a sensitive period ending with adolescence for the amygdala-mPFC circuit. Together, these findings suggest that resting-state functional architecture may arise from phasic patterns of functional connectivity elicited by environmental stimuli over the course of development on the order of years.
AB - Although the functional architecture of the brain is indexed by resting-state connectivity networks, little is currently known about the mechanisms through which these networks assemble into stable mature patterns. The current study posits and tests the long-term phasic molding hypothesis that resting-state networks are gradually shaped by recurring stimulus-elicited connectivity across development by examining how both stimulus-elicited and resting-state functional connections of the human brain emerge over development at the systems level. Using a sequential design following 4- to 18-year-olds over a 2 year period, we examined the predictive associations between stimulus-elicited and resting-state connectivity in amygdala-cortical circuitry as an exemplar case (given this network's protracted development across these ages). Age-related changes in amygdala functional connectivity converged on the same regions of medial prefrontal cortex (mPFC) and inferior frontal gyrus when elicited by emotional stimuli and when measured at rest. Consistent with the long-term phasic molding hypothesis, prospective analyses for both connections showed that the magnitude of an individual's stimulus-elicited connectivity unidirectionally predicted resting-state functional connectivity 2 years later. For the amygdala-mPFC connection, only stimulus-elicited connectivity during childhood and the transition to adolescence shaped future resting-state connectivity, consistent with a sensitive period ending with adolescence for the amygdala-mPFC circuit. Together, these findings suggest that resting-state functional architecture may arise from phasic patterns of functional connectivity elicited by environmental stimuli over the course of development on the order of years.
KW - Amygdala
KW - Development
KW - Prefrontal cortex
KW - Prospective
KW - Resting-state connectivity
KW - Stimulus-elicited connectivity
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U2 - 10.1523/JNEUROSCI.0598-16.2016
DO - 10.1523/JNEUROSCI.0598-16.2016
M3 - Article
C2 - 27122035
AN - SCOPUS:84966681528
SN - 0270-6474
VL - 36
SP - 4771
EP - 4784
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 17
ER -