Stereoselective Epoxidation Of Alkenes By Chloroperoxidase

Lowell P Hager (Inventor), Eric Allain (Inventor)

Research output: Patent


A method of converting olefins to chiral epoxides comprises combining an asymmetric aliphatic or aryl alkene substrate with a buffered chloroperoxidase solution to form a stabilized reaction mixture, and gradually adding hydrogen peroxide as a substrate oxidant, such that the chloroperoxidase catalyzes the conversion of the substrate to the corresponding epoxide in enantiomeric excess. The products of the invention are alkyl and aryl non-primary epoxides. The resulting preparations are enantiomerically pure, and may greatly enhance large-scale synthesis of stereoisomer products such as pharmaceuticals and pesticides.
Original languageEnglish (US)
U.S. patent number5358860
Filing date4/5/93
StatePublished - Oct 25 1994


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