Stereodivergent total synthesis of Δ9-tetrahydrocannabinols

Michael A. Schafroth; Giuseppe Zuccarello; Simon Krautwald; David Sarlah; Erick M. Carreira

doi:10.1002/anie.201408380

Stereodivergent total synthesis of Δ⁹-tetrahydrocannabinols

Michael A. Schafroth, Giuseppe Zuccarello, Simon Krautwald, David Sarlah, Erick M. Carreira

Research output: Contribution to journal › Article › peer-review

Abstract

All four stereoisomers of Δ⁹-tetrahydrocannabinol (Δ⁹-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.

Original language	English (US)
Pages (from-to)	13898-13901
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	53
Issue number	50
DOIs	https://doi.org/10.1002/anie.201408380
State	Published - Oct 10 2014
Externally published	Yes

Keywords

Dual catalysis
Stereodivergent synthesis
Tetrahydrocannabinol
Total synthesis

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Online availability

10.1002/anie.201408380

Library availability

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Cite this

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abstract = "All four stereoisomers of Δ9-tetrahydrocannabinol (Δ9-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.",

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