Stereodivergent total synthesis of Δ9-tetrahydrocannabinols

Michael A. Schafroth, Giuseppe Zuccarello, Simon Krautwald, David Sarlah, Erick M. Carreira

Research output: Contribution to journalArticlepeer-review


All four stereoisomers of Δ9-tetrahydrocannabinol (Δ9-THC) were synthesized in concise fashion using stereodivergent dual catalysis. Thus, following identical synthetic sequences and applying identical reaction conditions to the same set of starting materials, selective access to the four stereoisomers of THC was achieved in five steps.

Original languageEnglish (US)
Pages (from-to)13898-13901
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number50
StatePublished - Oct 10 2014
Externally publishedYes


  • Dual catalysis
  • Stereodivergent synthesis
  • Tetrahydrocannabinol
  • Total synthesis

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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