Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation

Research output: Contribution to journalShort survey

Abstract

Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

Original languageEnglish (US)
Pages (from-to)701-703
Number of pages3
JournalCell Stem Cell
Volume14
Issue number6
DOIs
StatePublished - Jun 5 2014

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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