Stem cells go soft

Pliant substrate surfaces enhance motor neuron differentiation

Research output: Contribution to journalShort survey

Abstract

Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

Original languageEnglish (US)
Pages (from-to)701-703
Number of pages3
JournalCell Stem Cell
Volume14
Issue number6
DOIs
StatePublished - Jun 5 2014

Fingerprint

Pluripotent Stem Cells
Motor Neurons
Stem Cells
Solar System

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

Cite this

Stem cells go soft : Pliant substrate surfaces enhance motor neuron differentiation. / Wang, Ning.

In: Cell Stem Cell, Vol. 14, No. 6, 05.06.2014, p. 701-703.

Research output: Contribution to journalShort survey

@article{5a084d87c47742b7b50da9f7060bcb10,
title = "Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation",
abstract = "Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.",
author = "Ning Wang",
year = "2014",
month = "6",
day = "5",
doi = "10.1016/j.stem.2014.05.007",
language = "English (US)",
volume = "14",
pages = "701--703",
journal = "Cell Stem Cell",
issn = "1934-5909",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Stem cells go soft

T2 - Pliant substrate surfaces enhance motor neuron differentiation

AU - Wang, Ning

PY - 2014/6/5

Y1 - 2014/6/5

N2 - Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

AB - Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

UR - http://www.scopus.com/inward/record.url?scp=84902125980&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902125980&partnerID=8YFLogxK

U2 - 10.1016/j.stem.2014.05.007

DO - 10.1016/j.stem.2014.05.007

M3 - Short survey

VL - 14

SP - 701

EP - 703

JO - Cell Stem Cell

JF - Cell Stem Cell

SN - 1934-5909

IS - 6

ER -