Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation

Research output: Contribution to journalShort survey


Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

Original languageEnglish (US)
Pages (from-to)701-703
Number of pages3
JournalCell Stem Cell
Issue number6
StatePublished - Jun 5 2014


ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Cell Biology

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