Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation

Ning Wang

doi:10.1016/j.stem.2014.05.007

Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation

Research output: Contribution to journal › Short survey › peer-review

Abstract

Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.

Original language	English (US)
Pages (from-to)	701-703
Number of pages	3
Journal	Cell Stem Cell
Volume	14
Issue number	6
DOIs	https://doi.org/10.1016/j.stem.2014.05.007
State	Published - Jun 5 2014

ASJC Scopus subject areas

Molecular Medicine
Genetics
Cell Biology

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10.1016/j.stem.2014.05.007

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title = "Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation",

abstract = "Derivation of motor neurons from human pluripotent stem cells is inefficient and requires complex culture protocols. Recently in Nature Materials, Sun et al. (2014) report that differentiating human pluripotent stem cells on soft substrates increases the efficiency of mature motor neuron differentiation by altering cytoskeletal mechanotransduction through the Hippo/YAP/Smad pathway.",

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Stem cells go soft: Pliant substrate surfaces enhance motor neuron differentiation

Abstract

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