Stem cell bioengineering at the interface of systems-based models and high-throughput platforms

Research output: Contribution to journalReview articlepeer-review

Abstract

Stem cell functions are regulated by a combination of molecular signals that are provided both intrinsically and from the local microenvironment. The complexity of these mechanisms has encouraged the use of interdisciplinary experimental strategies, such as bioengineering methods, to address fundamental questions in stem cell biology. These approaches have primarily aimed to (1) develop tools for the improved control of microenvironmental cues and genetic perturbations, (2) integrate high-throughput technologies to broaden the experimental state space and facilitate systematic examination of combinatorial signals, and (3) construct systems-based models to better define stem cell processes through an understanding of the interdependence of the individual signaling components. Cooperative advancements in these areas will continue to contribute to the evolution of stem cell-based therapeutics.

Original languageEnglish (US)
Pages (from-to)525-545
Number of pages21
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume4
Issue number6
DOIs
StatePublished - Nov 1 2012

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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