Stem Cell-based Therapies for Bone Repair

Peter I. Milner, Peter D. Clegg, Matthew C. Stewart

Research output: Contribution to journalReview articlepeer-review


This article provides an overview of the cellular and molecular events involved in bone repair and the current approaches to using stem cells as an adjunct to this process. The article emphasizes the key role of osteoprogenitor cells in the formation of bone and where the clinical applications of current research may lend themselves to large animal orthopaedics. The processes involved in osteogenic differentiation are presented and strategies for bone formation, including induction by osteogenic factors, bioscaffolds, and gene therapy, are reviewed.

Original languageEnglish (US)
Pages (from-to)299-314
Number of pages16
JournalVeterinary Clinics of North America - Equine Practice
Issue number2
StatePublished - Aug 2011


  • Bone repair
  • Horse
  • Osteogenesis
  • Stem cell

ASJC Scopus subject areas

  • Equine


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