Steered molecular dynamics and mechanical functions of proteins

B. Isralewitz, M. Gao, K. Schulten

Research output: Contribution to journalReview article

Abstract

Atomic force microscopy of single molecules, steered molecular dynamics and the theory of stochastic processes have established a new field that investigates mechanical functions of proteins, such as ligand-receptor binding/unbinding and elasticity of muscle proteins during stretching. The combination of these methods yields information on the energy landscape that controls mechanical function and on the force-bearing components of proteins, as well as on the underlying physical mechanisms.

Original languageEnglish (US)
Pages (from-to)224-230
Number of pages7
JournalCurrent Opinion in Structural Biology
Volume11
Issue number2
DOIs
StatePublished - Apr 1 2001

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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