Abstract
We investigate a DNA model that takes into account stacking interactions with neighbors up to three bases away. The model is a generalization of the well-known Peyrard-Bishop (PB) model and is motivated by studies that suggest that nearest-neighbor models for base-pair interaction in a DNA chain might not be enough to capture the mechanism and dynamics of DNA base-pair opening. We study stationary solutions of the modified model and investigate their stability. A comparison with the PB model reveals that under a wide range of parameter values the main characteristics of the original model -such as the hyperbolicity of the equilibrium at the origin- are preserved, but new types of stationary solutions emerge.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 209-216 |
| Number of pages | 8 |
| Journal | European Physical Journal E |
| Volume | 32 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jun 2010 |
ASJC Scopus subject areas
- Biotechnology
- Biophysics
- General Chemistry
- General Materials Science
- Surfaces and Interfaces
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