Stationary solutions for a modified Peyrard-Bishop DNA model with up to third-neighbor interactions

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Abstract

We investigate a DNA model that takes into account stacking interactions with neighbors up to three bases away. The model is a generalization of the well-known Peyrard-Bishop (PB) model and is motivated by studies that suggest that nearest-neighbor models for base-pair interaction in a DNA chain might not be enough to capture the mechanism and dynamics of DNA base-pair opening. We study stationary solutions of the modified model and investigate their stability. A comparison with the PB model reveals that under a wide range of parameter values the main characteristics of the original model -such as the hyperbolicity of the equilibrium at the origin- are preserved, but new types of stationary solutions emerge.

Original languageEnglish (US)
Pages (from-to)209-216
Number of pages8
JournalEuropean Physical Journal E
Volume32
Issue number2
DOIs
StatePublished - Jun 2010

ASJC Scopus subject areas

  • Biotechnology
  • Biophysics
  • General Chemistry
  • General Materials Science
  • Surfaces and Interfaces

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