Stain-less Staining for Computed Histopathology

David Mayerich; Michael J Walsh; Andre Kadjacsy-Balla; Partha S Ray; Stephen M Hewitt; Rohit Bhargava

doi:10.1142/S2339547815200010

Stain-less Staining for Computed Histopathology

David Mayerich, Michael J Walsh, Andre Kadjacsy-Balla, Partha S Ray, Stephen M Hewitt, Rohit Bhargava

Research output: Contribution to journal › Article › peer-review

Abstract

Dyes such as hematoxylin and eosin (H&E) and immunohistochemical stains have been increasingly used to visualize tissue composition in research and clinical practice. We present an alternative approach to obtain the same information using stain-free chemical imaging. Relying on Fourier transform infrared (FT-IR) spectroscopic imaging and computation, stainless computed histopathology can enable a rapid, digital, quantitative and non-perturbing visualization of morphology and multiple molecular epitopes simultaneously in a variety of research and clinical pathology applications.

Original language	English (US)
Pages (from-to)	27-31
Number of pages	5
Journal	Technology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1142/S2339547815200010
State	Published - Mar 2015

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title = "Stain-less Staining for Computed Histopathology",

abstract = "Dyes such as hematoxylin and eosin (H&E) and immunohistochemical stains have been increasingly used to visualize tissue composition in research and clinical practice. We present an alternative approach to obtain the same information using stain-free chemical imaging. Relying on Fourier transform infrared (FT-IR) spectroscopic imaging and computation, stainless computed histopathology can enable a rapid, digital, quantitative and non-perturbing visualization of morphology and multiple molecular epitopes simultaneously in a variety of research and clinical pathology applications.",

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AU - Mayerich, David

AU - Walsh, Michael J

AU - Kadjacsy-Balla, Andre

AU - Ray, Partha S

AU - Hewitt, Stephen M

AU - Bhargava, Rohit

PY - 2015/3

Y1 - 2015/3

N2 - Dyes such as hematoxylin and eosin (H&E) and immunohistochemical stains have been increasingly used to visualize tissue composition in research and clinical practice. We present an alternative approach to obtain the same information using stain-free chemical imaging. Relying on Fourier transform infrared (FT-IR) spectroscopic imaging and computation, stainless computed histopathology can enable a rapid, digital, quantitative and non-perturbing visualization of morphology and multiple molecular epitopes simultaneously in a variety of research and clinical pathology applications.

AB - Dyes such as hematoxylin and eosin (H&E) and immunohistochemical stains have been increasingly used to visualize tissue composition in research and clinical practice. We present an alternative approach to obtain the same information using stain-free chemical imaging. Relying on Fourier transform infrared (FT-IR) spectroscopic imaging and computation, stainless computed histopathology can enable a rapid, digital, quantitative and non-perturbing visualization of morphology and multiple molecular epitopes simultaneously in a variety of research and clinical pathology applications.

U2 - 10.1142/S2339547815200010

DO - 10.1142/S2339547815200010

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SN - 2339-5478

VL - 3

SP - 27

EP - 31

JO - Technology

JF - Technology

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Stain-less Staining for Computed Histopathology

Abstract

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