Stain-less Staining for Computed Histopathology

David Mayerich, Michael J Walsh, Andre Kadjacsy-Balla, Partha S Ray, Stephen M Hewitt, Rohit Bhargava

Research output: Contribution to journalArticlepeer-review


Dyes such as hematoxylin and eosin (H&E) and immunohistochemical stains have been increasingly used to visualize tissue composition in research and clinical practice. We present an alternative approach to obtain the same information using stain-free chemical imaging. Relying on Fourier transform infrared (FT-IR) spectroscopic imaging and computation, stainless computed histopathology can enable a rapid, digital, quantitative and non-perturbing visualization of morphology and multiple molecular epitopes simultaneously in a variety of research and clinical pathology applications.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
Issue number1
StatePublished - Mar 2015


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