Stable retrovirus and methods of use

Halong N Vu (Inventor), Daniel W Pack (Inventor), Joshua Ramsey (Inventor)

Research output: Patent


The present invention is a mutant retroviral protease which confers an increase in retroviral stability. Retroviruses expressing the instant mutant retroviral protease exhibit at least a 2-fold increase in infectivity half-life as compared to wild-type retrovirus. Unexpectedly, a Gly119Glu mutation in the protease enhances retroviral stability in the presence of various wild-type envelope proteins including wild-type amphotropic, ecotropic and 10A1 murine leukemia viruses. The improved stability of the mutant retrovirus leads to more facile virus production and enhanced infection efficiency.
Original languageEnglish (US)
U.S. patent number7485446
Filing date2/21/07
StatePublished - Feb 3 2009


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