TY - JOUR
T1 - Stability and Dynamics of Virus Capsids Described by Coarse-Grained Modeling
AU - Arkhipov, Anton
AU - Freddolino, Peter L.
AU - Schulten, Klaus
PY - 2006/12
Y1 - 2006/12
N2 - We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.
AB - We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.
UR - https://www.scopus.com/pages/publications/33845204189
UR - https://www.scopus.com/inward/citedby.url?scp=33845204189&partnerID=8YFLogxK
U2 - 10.1016/j.str.2006.10.003
DO - 10.1016/j.str.2006.10.003
M3 - Article
C2 - 17161367
AN - SCOPUS:33845204189
SN - 0969-2126
VL - 14
SP - 1767
EP - 1777
JO - Structure
JF - Structure
IS - 12
ER -