Stability and Dynamics of Virus Capsids Described by Coarse-Grained Modeling

Anton Arkhipov, Peter L. Freddolino, Klaus Schulten

Research output: Contribution to journalArticlepeer-review

Abstract

We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.

Original languageEnglish (US)
Pages (from-to)1767-1777
Number of pages11
JournalStructure
Volume14
Issue number12
DOIs
StatePublished - Dec 2006

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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