Stability and Dynamics of Virus Capsids Described by Coarse-Grained Modeling

Anton Arkhipov; Peter L. Freddolino; Klaus Schulten

doi:10.1016/j.str.2006.10.003

Stability and Dynamics of Virus Capsids Described by Coarse-Grained Modeling

Anton Arkhipov, Peter L. Freddolino, Klaus Schulten

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.

Original language	English (US)
Pages (from-to)	1767-1777
Number of pages	11
Journal	Structure
Volume	14
Issue number	12
DOIs	https://doi.org/10.1016/j.str.2006.10.003
State	Published - Dec 2006

ASJC Scopus subject areas

Structural Biology
Molecular Biology

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abstract = "We report a study of the structural dynamics of viral capsids, simulated on a microsecond timescale, by employing a coarse-graining molecular dynamics method. The method was calibrated against an all-atom simulation of one complete virus. Among the studied capsids, some collapsed rapidly, while others were found to be stable. Interlocking between coat proteins is found to be a key factor determining the stability of the capsids.",

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