Spray sonocrystallization

Hyo Na Kim; John R.G. Sander; Brad W. Zeiger; Kenneth S. Suslick

doi:10.1021/acs.cgd.5b00072

Spray sonocrystallization

Hyo Na Kim, John R.G. Sander, Brad W. Zeiger, Kenneth S. Suslick

Research output: Contribution to journal › Article › peer-review

Abstract

A spray sonocrystallization (SSC) method is described here for the crystallization of pharmaceutical agents that provides for a tunable crystal size and narrow size distribution in the submicron regime. SSC uses a tapped, flow-through ultrasonic horn (20 kHz) to spray very fine droplets of the solute-containing solution into a continuous flow of antisolvent which induces immediate crystallization with extremely effective mixing. The analgesic 2-carboxyphenyl salicylate (CPS, salsalate) was explored as a test case. The diameter of sonocrystallized CPS could be controlled systematically over the range from 75 to 175 nm. The addition of low concentrations of polyvinylpyrrolidone or sodium dodecyl sulfate to the antisolvent maintained dispersion of the particles without significantly changing particle size or distribution.

Original language	English (US)
Pages (from-to)	1564-1567
Number of pages	4
Journal	Crystal Growth and Design
Volume	15
Issue number	4
DOIs	https://doi.org/10.1021/acs.cgd.5b00072
State	Published - Apr 1 2015

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

Online availability

10.1021/acs.cgd.5b00072

Library availability

Discover UIUC Full Text

Cite this

@article{5feba5343eb349daa152731cadcce232,

title = "Spray sonocrystallization",

abstract = "A spray sonocrystallization (SSC) method is described here for the crystallization of pharmaceutical agents that provides for a tunable crystal size and narrow size distribution in the submicron regime. SSC uses a tapped, flow-through ultrasonic horn (20 kHz) to spray very fine droplets of the solute-containing solution into a continuous flow of antisolvent which induces immediate crystallization with extremely effective mixing. The analgesic 2-carboxyphenyl salicylate (CPS, salsalate) was explored as a test case. The diameter of sonocrystallized CPS could be controlled systematically over the range from 75 to 175 nm. The addition of low concentrations of polyvinylpyrrolidone or sodium dodecyl sulfate to the antisolvent maintained dispersion of the particles without significantly changing particle size or distribution.",

author = "Kim, {Hyo Na} and Sander, {John R.G.} and Zeiger, {Brad W.} and Suslick, {Kenneth S.}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

month = apr,

day = "1",

doi = "10.1021/acs.cgd.5b00072",

language = "English (US)",

volume = "15",

pages = "1564--1567",

journal = "Crystal Growth and Design",

issn = "1528-7483",

publisher = "American Chemical Society",

number = "4",

}

TY - JOUR

T1 - Spray sonocrystallization

AU - Kim, Hyo Na

AU - Sander, John R.G.

AU - Zeiger, Brad W.

AU - Suslick, Kenneth S.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - A spray sonocrystallization (SSC) method is described here for the crystallization of pharmaceutical agents that provides for a tunable crystal size and narrow size distribution in the submicron regime. SSC uses a tapped, flow-through ultrasonic horn (20 kHz) to spray very fine droplets of the solute-containing solution into a continuous flow of antisolvent which induces immediate crystallization with extremely effective mixing. The analgesic 2-carboxyphenyl salicylate (CPS, salsalate) was explored as a test case. The diameter of sonocrystallized CPS could be controlled systematically over the range from 75 to 175 nm. The addition of low concentrations of polyvinylpyrrolidone or sodium dodecyl sulfate to the antisolvent maintained dispersion of the particles without significantly changing particle size or distribution.

AB - A spray sonocrystallization (SSC) method is described here for the crystallization of pharmaceutical agents that provides for a tunable crystal size and narrow size distribution in the submicron regime. SSC uses a tapped, flow-through ultrasonic horn (20 kHz) to spray very fine droplets of the solute-containing solution into a continuous flow of antisolvent which induces immediate crystallization with extremely effective mixing. The analgesic 2-carboxyphenyl salicylate (CPS, salsalate) was explored as a test case. The diameter of sonocrystallized CPS could be controlled systematically over the range from 75 to 175 nm. The addition of low concentrations of polyvinylpyrrolidone or sodium dodecyl sulfate to the antisolvent maintained dispersion of the particles without significantly changing particle size or distribution.

UR - http://www.scopus.com/inward/record.url?scp=84926345645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84926345645&partnerID=8YFLogxK

U2 - 10.1021/acs.cgd.5b00072

DO - 10.1021/acs.cgd.5b00072

M3 - Article

AN - SCOPUS:84926345645

SN - 1528-7483

VL - 15

SP - 1564

EP - 1567

JO - Crystal Growth and Design

JF - Crystal Growth and Design

IS - 4

ER -

Spray sonocrystallization

Abstract

ASJC Scopus subject areas

Online availability

Library availability

Related links

Fingerprint

Cite this