The Spitzer Space Telescope has three science instruments (IRAC, MIPS, and IRS) that can take images at 3.6, 4.5, 5.8, 8.0, 24, 70, and 160 μm, spectra over 5-38 μm, and spectral energy distribution over 52-100 μm. The Spitzer archive contains targeted imaging observations for more than 100 PNe. Spitzer legacy surveys, particularly the GLIMPSE survey of the Galactic plane, contain additional serendipitous imaging observations of PNe. Spitzer imaging and spectroscopic observations of PNe allow us to investigate atomic/molecular line emission and dust continuum from the nebulae as well as circumstellar dust disks around the central stars. Highlights of Spitzer observations of PNe are reviewed in this paper.