TY - JOUR
T1 - Spine plasticity in the motor cortex
AU - Yu, Xinzhu
AU - Zuo, Yi
N1 - Funding Information:
We thank David States and Drs. Ju Lu, Denise Garcia for critical comments on this manuscript. This work was supported by grants from the Ellison Medical Foundation, the DANA Foundation, and the National Institutes of Aging to Y.Z.
Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/2
Y1 - 2011/2
N2 - Dendritic spines are the postsynaptic sites of the majority of excitatory synapses in the mammalian central nervous system. The morphology and dynamics of dendritic spines change throughout the lifespan of animals, in response to novel experiences and neuropathologies. New spines form rapidly as animals learn new tasks or experience novel sensory stimulations. This is followed by a selective elimination of previously existing spines, leading to significant synaptic remodeling. In the brain damaged by injuries or neurological diseases, spines in surviving cortical regions turn over substantially, potentially forming new synaptic connections to adopt the function lost in the damaged region. These findings suggest that spine plasticity plays important roles in the formation and maintenance of a functional neural circuitry.
AB - Dendritic spines are the postsynaptic sites of the majority of excitatory synapses in the mammalian central nervous system. The morphology and dynamics of dendritic spines change throughout the lifespan of animals, in response to novel experiences and neuropathologies. New spines form rapidly as animals learn new tasks or experience novel sensory stimulations. This is followed by a selective elimination of previously existing spines, leading to significant synaptic remodeling. In the brain damaged by injuries or neurological diseases, spines in surviving cortical regions turn over substantially, potentially forming new synaptic connections to adopt the function lost in the damaged region. These findings suggest that spine plasticity plays important roles in the formation and maintenance of a functional neural circuitry.
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U2 - 10.1016/j.conb.2010.07.010
DO - 10.1016/j.conb.2010.07.010
M3 - Review article
C2 - 20728341
AN - SCOPUS:79952072917
SN - 0959-4388
VL - 21
SP - 169
EP - 174
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
IS - 1
ER -