SPICE circuit simulation of the electrical response of a semiconductor membrane to a single-stranded DNA translocating through a nanopore

Amandine Leroux, Jacques Destiné, Benoît Vanderheyden, Maria E. Gracheva, Jean Pierre Leburton

Research output: Contribution to journalArticlepeer-review

Abstract

In this paper, we describe a circuit-element model for the electric detection of biomolecules in translocation through a nanopore in a semiconductor-oxide-semiconductor (SOS) membrane. The biomolecules are simulated as a superposition of individual charges moving through the nanopore and inducing a charge variation on the membrane electrodes that is modeled as a current source. The SOS membrane is discretized into interconnected elementary circuit elements. The model is tested on the translocation of 11 base single-stranded C3AC7 DNA molecule, for which the electric signal shows good qualitative agreement with the multiscale device approach of Gracheva et al., while quantifying the low-pass filtering in the membrane. Overall, the model confirms the possibility of identifying the sequence of the DNA bases electrically.

Original languageEnglish (US)
Article number5419115
Pages (from-to)322-329
Number of pages8
JournalIEEE Transactions on Nanotechnology
Volume9
Issue number3
DOIs
StatePublished - May 2010

Keywords

  • Circuit modeling
  • DNA sequencing
  • Solid-state nanopore
  • SPICE simulation

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Computer Science Applications

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