Spectroscopic optical coherence tomography and microscopy

Amy L. Oldenburg; Chenyang Xu; Stephen A. Boppart

doi:10.1109/JSTQE.2007.910292

Spectroscopic optical coherence tomography and microscopy

Amy L. Oldenburg, Chenyang Xu, Stephen A. Boppart

Research output: Contribution to journal › Article › peer-review

Abstract

Imaging biological tissues using optical coherence tomography is enhanced with spectroscopic analysis, providing new metrics for functional imaging. Recent advances in spectroscopic optical coherence tomography (SOCT) include techniques for the discrimination of endogenous tissue types and for the detection of exogenous contrast agents. In this paper, we review these techniques and their associated signal processing algorithms, while highlighting their potential for biomedical applications. We unify the theoretical framework for time- and frequency-domain SOCT and introduce a noise correction method. Differences between spectroscopic Mie scatterers are demonstrated with SOCT, and spectroscopic imaging of macrophage and fibroblast cells in a 3-D scaffold is shown.

Original language	English (US)
Pages (from-to)	1629-1640
Number of pages	12
Journal	IEEE Journal on Selected Topics in Quantum Electronics
Volume	13
Issue number	6
DOIs	https://doi.org/10.1109/JSTQE.2007.910292
State	Published - Nov 2007

Keywords

Biophotonics
Functional imaging
Molecular imaging
Optical coherence tomography
Spectroscopy
Tissue

ASJC Scopus subject areas

Electrical and Electronic Engineering
Atomic and Molecular Physics, and Optics

Online availability

10.1109/JSTQE.2007.910292

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title = "Spectroscopic optical coherence tomography and microscopy",

abstract = "Imaging biological tissues using optical coherence tomography is enhanced with spectroscopic analysis, providing new metrics for functional imaging. Recent advances in spectroscopic optical coherence tomography (SOCT) include techniques for the discrimination of endogenous tissue types and for the detection of exogenous contrast agents. In this paper, we review these techniques and their associated signal processing algorithms, while highlighting their potential for biomedical applications. We unify the theoretical framework for time- and frequency-domain SOCT and introduce a noise correction method. Differences between spectroscopic Mie scatterers are demonstrated with SOCT, and spectroscopic imaging of macrophage and fibroblast cells in a 3-D scaffold is shown.",

keywords = "Biophotonics, Functional imaging, Molecular imaging, Optical coherence tomography, Spectroscopy, Tissue",

author = "Oldenburg, {Amy L.} and Chenyang Xu and Boppart, {Stephen A.}",

note = "Funding Information: Manuscript received September 6, 2007; revised October 4, 2007. This work was supported in part by the National Institutes of Health under the Roadmap Initiative, in part by the National Institute of Biomedical Imaging and Bioengineering under Grant 1 R21 EB005321, Grant 1 R01 EB005221, and Grant 1 R01 EB001777, in part by the National Science Foundation under Grant BES 03-47747, Grant BES 05-19920, and Grant BES 06-19257, and in part by the Siteman Center of Cancer Nanotechnology Excellence, through the University of Illinois Center for Nanoscale Science and Technology under Grant NCI U54-CA119342-01. Additional information can be found at http://biophotonics.uiuc.edu.",

year = "2007",

month = nov,

doi = "10.1109/JSTQE.2007.910292",

language = "English (US)",

volume = "13",

pages = "1629--1640",

journal = "IEEE Journal on Selected Topics in Quantum Electronics",

issn = "1077-260X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

number = "6",

}

TY - JOUR

T1 - Spectroscopic optical coherence tomography and microscopy

AU - Oldenburg, Amy L.

AU - Xu, Chenyang

AU - Boppart, Stephen A.

N1 - Funding Information: Manuscript received September 6, 2007; revised October 4, 2007. This work was supported in part by the National Institutes of Health under the Roadmap Initiative, in part by the National Institute of Biomedical Imaging and Bioengineering under Grant 1 R21 EB005321, Grant 1 R01 EB005221, and Grant 1 R01 EB001777, in part by the National Science Foundation under Grant BES 03-47747, Grant BES 05-19920, and Grant BES 06-19257, and in part by the Siteman Center of Cancer Nanotechnology Excellence, through the University of Illinois Center for Nanoscale Science and Technology under Grant NCI U54-CA119342-01. Additional information can be found at http://biophotonics.uiuc.edu.

PY - 2007/11

Y1 - 2007/11

N2 - Imaging biological tissues using optical coherence tomography is enhanced with spectroscopic analysis, providing new metrics for functional imaging. Recent advances in spectroscopic optical coherence tomography (SOCT) include techniques for the discrimination of endogenous tissue types and for the detection of exogenous contrast agents. In this paper, we review these techniques and their associated signal processing algorithms, while highlighting their potential for biomedical applications. We unify the theoretical framework for time- and frequency-domain SOCT and introduce a noise correction method. Differences between spectroscopic Mie scatterers are demonstrated with SOCT, and spectroscopic imaging of macrophage and fibroblast cells in a 3-D scaffold is shown.

AB - Imaging biological tissues using optical coherence tomography is enhanced with spectroscopic analysis, providing new metrics for functional imaging. Recent advances in spectroscopic optical coherence tomography (SOCT) include techniques for the discrimination of endogenous tissue types and for the detection of exogenous contrast agents. In this paper, we review these techniques and their associated signal processing algorithms, while highlighting their potential for biomedical applications. We unify the theoretical framework for time- and frequency-domain SOCT and introduce a noise correction method. Differences between spectroscopic Mie scatterers are demonstrated with SOCT, and spectroscopic imaging of macrophage and fibroblast cells in a 3-D scaffold is shown.

KW - Biophotonics

KW - Functional imaging

KW - Molecular imaging

KW - Optical coherence tomography

KW - Spectroscopy

KW - Tissue

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JO - IEEE Journal on Selected Topics in Quantum Electronics

JF - IEEE Journal on Selected Topics in Quantum Electronics

IS - 6

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Spectroscopic optical coherence tomography and microscopy

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