@article{8947df68e6a64e4fbf343ec951d56ef7,
title = "Specific-locus mutation assay in Zea may. A report of the U.S. environmental protection agency Gene-Tox program",
abstract = "The use of the angiosperm Zea mays in assays for the induction of mutations at specific genetic loci is discussed. The effect of chemical mutagens on 3 genetic end points is evaluated. The end points surveyed were the loss of the phenotype of dominant alleles in heterozygotes, the induction of segregating point mutations in M2 plants, and the induction of forward and reverse mutations in pollen grains. Maize is sensitive to a wide range of mutagens and has the capacity to activate promutagens. This plant has been used to study mutagenesis under both laboratory and in situ conditions.",
author = "Plewa, {Michael J.}",
note = "Funding Information: By acceptance of this article the publisher or recipient acknowledges the U.S. Government's right to retain a nonexclusive, royalty-free license in and to any copyright covering the article. * Work Group Report prepared for the Gene-Tox Program (Office of Toxic Substances, Office of Pesticides and Toxic Substances, U.S. Environmental Protection Agency, Washington, DC). The author is a member of the Gene-Tox Work Group on Higher Plant Genetic and Cytogenetlc Assays. Although the review described in this article has been funded wholly or in part by the United States Environmental Protection Agency through Interagency Agreement DOE 40-1123-80, EPA No. 80-D-X0953, to the Oak Ridge National Laboratory, it has not been subjected to the Agency's required peer and policy review and, therefore, does not necessarily reflect the views of the Agency and no official endorsement should be inferred. The protocols stated, suggested use of the assay in a screening program, and research recommended should not be taken to represent Agency policy on these matters.",
year = "1982",
month = nov,
doi = "10.1016/0165-1110(82)90049-5",
language = "English (US)",
volume = "99",
pages = "317--337",
journal = "Mutation Research - Reviews in Genetic Toxicology",
issn = "0165-1110",
publisher = "Elsevier BV",
number = "3",
}