There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A micro fluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.

Original languageEnglish (US)
Pages (from-to)1567-1572
Number of pages6
JournalAdvanced Materials
Issue number9
StatePublished - Mar 4 2015


  • Glioblastoma
  • Gradient
  • Hydrogel
  • Microfluidics
  • Tumor microenvironment

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering


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