Abstract
There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A micro fluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1567-1572 |
| Number of pages | 6 |
| Journal | Advanced Materials |
| Volume | 27 |
| Issue number | 9 |
| DOIs | |
| State | Published - Mar 4 2015 |
Keywords
- Glioblastoma
- Gradient
- Hydrogel
- Microfluidics
- Tumor microenvironment
ASJC Scopus subject areas
- General Materials Science
- Mechanics of Materials
- Mechanical Engineering