Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Amr A. Abdeen; Junmin Lee; Samuel H. Mo; Kristopher A. Kilian

doi:10.1039/c5tb01294e

Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Amr A. Abdeen, Junmin Lee, Samuel H. Mo, Kristopher A. Kilian

Research output: Contribution to journal › Article › peer-review

Abstract

The spatiotemporal coordination of angiogenesis in synthetic materials is important for mimicking natural tissue morphogenesis. Here we report patterned hydrogel encapsulation of mesenchymal stem cells to direct endothelial tubulogenesis in co-culture. Tubulogenesis occurs preferentially over MSC patterns, suggesting this strategy may prove useful in guiding the design of heterotypic engineered tissues.

Original language	English (US)
Pages (from-to)	7896-7898
Number of pages	3
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	40
DOIs	https://doi.org/10.1039/c5tb01294e
State	Published - 2015

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

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10.1039/c5tb01294e

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title = "Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis",

abstract = "The spatiotemporal coordination of angiogenesis in synthetic materials is important for mimicking natural tissue morphogenesis. Here we report patterned hydrogel encapsulation of mesenchymal stem cells to direct endothelial tubulogenesis in co-culture. Tubulogenesis occurs preferentially over MSC patterns, suggesting this strategy may prove useful in guiding the design of heterotypic engineered tissues.",

author = "Abdeen, {Amr A.} and Junmin Lee and Mo, {Samuel H.} and Kilian, {Kristopher A.}",

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AU - Lee, Junmin

AU - Mo, Samuel H.

AU - Kilian, Kristopher A.

N1 - Publisher Copyright: © The Royal Society of Chemistry 2015.

PY - 2015

Y1 - 2015

N2 - The spatiotemporal coordination of angiogenesis in synthetic materials is important for mimicking natural tissue morphogenesis. Here we report patterned hydrogel encapsulation of mesenchymal stem cells to direct endothelial tubulogenesis in co-culture. Tubulogenesis occurs preferentially over MSC patterns, suggesting this strategy may prove useful in guiding the design of heterotypic engineered tissues.

AB - The spatiotemporal coordination of angiogenesis in synthetic materials is important for mimicking natural tissue morphogenesis. Here we report patterned hydrogel encapsulation of mesenchymal stem cells to direct endothelial tubulogenesis in co-culture. Tubulogenesis occurs preferentially over MSC patterns, suggesting this strategy may prove useful in guiding the design of heterotypic engineered tissues.

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Spatially defined stem cell-laden hydrogel islands for directing endothelial tubulogenesis

Abstract

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