@article{d16ae8b38c60478f914598d364588ee9,
title = "Spatial Organization of Superparamagnetic Iron Oxide Nanoparticles in/on Nano/Microsized Carriers Modulates the Magnetic Resonance Signal",
abstract = " Superparamagnetic iron oxide nanoparticles (SPIONs) are often encapsulated into drug-carrying nano/microsized particles for simultaneous magnetic resonance (MR) imaging and treatment of diseased tissues. Unfortunately, encapsulated SPIONs may have a limited ability to modulate the T 2 -weighted relaxation of water protons, but this insight has not been examined systematically. This study demonstrates that SPIONs immobilized on 200 nm diameter poly(lactic-co-glycolic acid) (PLGA) nanoparticles using Pickering emulsification present 18-fold higher relaxivity than encapsulated SPIONs and 1.5-fold higher relaxivity than free SPIONs. In contrast, the SPIONs immobilized on 10 μm diameter PLGA particles exhibit a minor increase in MR relaxivity. This interesting finding will significantly impact current efforts to synthesize and assemble advanced MR contrast agents.",
author = "Lee, {Min Kyung} and Clay, {Nicholas E.} and Eunkyung Ko and Smith, {Cartney E.} and Lin Chen and Nicholas Cho and Sung, {Hak Joon} and Luisa Dipietro and Jonghwi Lee and Hyunjoon Kong",
note = "Funding Information: The authors thank B. Odintsov and R. Larsen at the Beckman Institute for Advanced Science and Technology for help with MRI. Mass spectral analyses were provided by the Mass Spectrometry Laboratory, School of Chemical Sciences, and TEM and DLS were carried out in the Frederick Seitz Materials Research Laboratory Central Facilities at the University of Illinois. Work was funded by the National Institutes of Health (1R01 HL109192 to H.K., Chemistry-Biology Interface Training Grant 5T32-GM070421 to C.E.S., National Institute of Biomedical Imaging and Bioengineering Training Grant T32EB019944 to E.K.). N.E.C. would like to thank the financial support of the Dow Chemical Company as well. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2018 American Chemical Society.",
year = "2018",
month = dec,
day = "18",
doi = "10.1021/acs.langmuir.8b01477",
language = "English (US)",
volume = "34",
pages = "15276--15282",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "50",
}