Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo

Hee Sun Han; John D. Martin; Jungmin Lee; Daniel K. Harris; Dai Fukumura; Rakesh K. Jain; Moungi Bawendi

doi:10.1002/anie.201208331

Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo

Hee Sun Han, John D. Martin, Jungmin Lee, Daniel K. Harris, Dai Fukumura, Rakesh K. Jain, Moungi Bawendi

Research output: Contribution to journal › Article › peer-review

Abstract

Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.

Original language	English (US)
Pages (from-to)	1414-1419
Number of pages	6
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	5
DOIs	https://doi.org/10.1002/anie.201208331
State	Published - Jan 28 2013
Externally published	Yes

Keywords

cancer
ligand design
nanoparticles
quantum dots
zwitterions

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Online availability

10.1002/anie.201208331

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AU - Jain, Rakesh K.

AU - Bawendi, Moungi

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KW - ligand design

KW - nanoparticles

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KW - zwitterions

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Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo

Abstract

Keywords

ASJC Scopus subject areas

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