Spatial charge configuration regulates nanoparticle transport and binding behavior in vivo

Hee Sun Han, John D. Martin, Jungmin Lee, Daniel K. Harris, Dai Fukumura, Rakesh K. Jain, Moungi Bawendi

Research output: Contribution to journalArticlepeer-review

Abstract

Detailed arrangements: A new set of zwitterionic quantum dots were synthesized and used to study the influence of microscopic charge arrangements on the in vivo behavior of nanoparticles. Experiments using cultured cells and live mice demonstrate that the microscopic arrangement of surface charges strongly influences nonspecific binding, clearance behavior, and in vivo transport of nanoparticles.

Original languageEnglish (US)
Pages (from-to)1414-1419
Number of pages6
JournalAngewandte Chemie - International Edition
Volume52
Issue number5
DOIs
StatePublished - Jan 28 2013
Externally publishedYes

Keywords

  • cancer
  • ligand design
  • nanoparticles
  • quantum dots
  • zwitterions

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

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