TY - JOUR
T1 - Soy improves cardiometabolic health and cecal microbiota in female low-fit rats
AU - Cross, Tzu Wen L.
AU - Zidon, Terese M.
AU - Welly, Rebecca J.
AU - Park, Young Min
AU - Britton, Steven L.
AU - Koch, Lauren G.
AU - Rottinghaus, George E.
AU - De Godoy, Maria R.Cattai
AU - Padilla, Jaume
AU - Swanson, Kelly S.
AU - Vieira-Potter, Victoria J.
N1 - Funding Information:
We thank Olivia Stricklin, Bridget Upton, and Leighton McCabe for assisting with data collection and animal care. We thank Alvaro Hernandez and Chris Wright from W. M. Keck Center for Biotechnology at the University of Illinois for expertise and help with the Mi-Seq Illumina sequencing. We acknowledge the expert care of the rat colony provided by Lori Heckenkamp and Shelby Raupp. We thank the R script written and generously shared by Dr. Kjersti Aagaard and Dr. Jun Ma from the Baylor College of Medicine. Present address of Y-MP: Anschutz Medical Campus at the University of Colorado, Denver. (CBIS to V. Vieira-Potter) P50AT00627, NIH K01HL125503 (to J.P.). The LCR-HCR rat model system was funded by the Office of Research Infrastructure Programs grant P40OD021331 (to LGK and SLB) from the National Institutes of Health. Contact LGK lgkoch@ umich.edu or SLB brittons@umich.edu for information on the LCR and HCR rats: these rat models are maintained as an international resource with support from the Department of Anesthesiology at the University of Michigan, Ann Arbor, Michigan.
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and metabolic dysfunction for reasons that are unclear. The gut microbiota have been linked with the development of obesity and metabolic dysfunction. We aimed to determine the impact of soy on cardiometabolic health, adipose tissue inflammation, and the cecal microbiota in ovariectomized (OVX) rats bred for low-running capacity (LCR), a model that has been previously shown to mimic human menopause compared to sham-operated (SHM) intact control LCR rats. In this study, soy consumption, without affecting energy intake or physical activity, significantly improved insulin sensitivity and body composition of OVX rats bred for low-running capacity. Furthermore, soy significantly improved blood lipid profile, adipose tissue inflammation, and aortic stiffness of LCR rats. Compared to a soy-free control diet, soy significantly shifted the cecal microbial community of LCR rats, resulting in a lower Firmicutes:Bacteroidetes ratio. Correlations among metabolic parameters and cecal bacterial taxa identified in this study suggest that taxa Prevotella, Dorea, and Phascolarctobacterium may be taxa of interest. Our results suggest that dietary soy ameliorates adiposity, insulin sensitivity, adipose tissue inflammation, and arterial stiffness and exerts a beneficial shift in gut microbial communities in a rat model that mimics human menopause.
AB - Phytoestrogen-rich soy is known to ameliorate menopause-associated obesity and metabolic dysfunction for reasons that are unclear. The gut microbiota have been linked with the development of obesity and metabolic dysfunction. We aimed to determine the impact of soy on cardiometabolic health, adipose tissue inflammation, and the cecal microbiota in ovariectomized (OVX) rats bred for low-running capacity (LCR), a model that has been previously shown to mimic human menopause compared to sham-operated (SHM) intact control LCR rats. In this study, soy consumption, without affecting energy intake or physical activity, significantly improved insulin sensitivity and body composition of OVX rats bred for low-running capacity. Furthermore, soy significantly improved blood lipid profile, adipose tissue inflammation, and aortic stiffness of LCR rats. Compared to a soy-free control diet, soy significantly shifted the cecal microbial community of LCR rats, resulting in a lower Firmicutes:Bacteroidetes ratio. Correlations among metabolic parameters and cecal bacterial taxa identified in this study suggest that taxa Prevotella, Dorea, and Phascolarctobacterium may be taxa of interest. Our results suggest that dietary soy ameliorates adiposity, insulin sensitivity, adipose tissue inflammation, and arterial stiffness and exerts a beneficial shift in gut microbial communities in a rat model that mimics human menopause.
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U2 - 10.1038/s41598-017-08965-0
DO - 10.1038/s41598-017-08965-0
M3 - Article
C2 - 28835674
AN - SCOPUS:85028036673
VL - 7
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 9261
ER -