TY - CHAP
T1 - Source impacts on and cardiorespiratory effects of reactive oxygen species generated by water-soluble PM2.5 across the eastern United States
AU - Bates, Josephine T.
AU - Weber, Rodney J.
AU - Abrams, Joseph
AU - Verma, Vishal
AU - Fang, Ting
AU - Ivey, Cesunica
AU - Liu, Cong
AU - Klein, Mitchel
AU - Strickland, Matthew J.
AU - Sarnat, Stefanie E.
AU - Chang, Howard H.
AU - Mulholland, James A.
AU - Tolbert, Paige E.
AU - Russell, Armistead G.
N1 - Publisher Copyright:
© Springer International Publishing AG 2018.
PY - 2018
Y1 - 2018
N2 - It is hypothesized that PM2.5 with high oxidative potential (OP) can catalytically generate reactive oxygen species (ROS) in excess of the body’s antioxidant capacity, leading to oxidative stress. Therefore, two advanced methods for conducting source apportionment, along with field experiments characterizing air quality, are used to identify the sources of PM2.5 with high OP and relate them to acute health effects. The field study measured OP of ambient water-soluble PM2.5 using a dithiothreitol (DTT) assay at four sites across the Southeastern United States from June 2012 to June 2013. Source apportionment was performed on collocated speciated PM2.5 samples using the Chemical Mass Balance Method with ensemble-trained profiles in Atlanta, GA and CMAQ-DDM for Atlanta and all other measurement sites (Yorkville, GA, Centerville, AL, and Birmingham, AL). Source-OP relationships were investigated using least squares linear regression. The model for Atlanta, GA was applied to PM2.5 source impacts from 1998–2010 to estimate long-term trends in ambient PM2.5 OP for use in population-level acute epidemiologic studies. Biomass burning contributes the largest fraction to total historical OP in Atlanta, followed by light-duty gasoline vehicles and heavy-duty diesel vehicles (43, 22 and 17%, respectively). Results find significant associations between estimated OP and emergency department visits related to congestive heart failure and asthma/wheezing attacks, supporting the hypothesis that PM2.5 health effects are, in part, due to oxidative stress and that OP is a useful indicator of PM2.5 health impacts. Finally, controlling PM2.5 sources with high OP, like biomass burning, may help prevent acute health effects.
AB - It is hypothesized that PM2.5 with high oxidative potential (OP) can catalytically generate reactive oxygen species (ROS) in excess of the body’s antioxidant capacity, leading to oxidative stress. Therefore, two advanced methods for conducting source apportionment, along with field experiments characterizing air quality, are used to identify the sources of PM2.5 with high OP and relate them to acute health effects. The field study measured OP of ambient water-soluble PM2.5 using a dithiothreitol (DTT) assay at four sites across the Southeastern United States from June 2012 to June 2013. Source apportionment was performed on collocated speciated PM2.5 samples using the Chemical Mass Balance Method with ensemble-trained profiles in Atlanta, GA and CMAQ-DDM for Atlanta and all other measurement sites (Yorkville, GA, Centerville, AL, and Birmingham, AL). Source-OP relationships were investigated using least squares linear regression. The model for Atlanta, GA was applied to PM2.5 source impacts from 1998–2010 to estimate long-term trends in ambient PM2.5 OP for use in population-level acute epidemiologic studies. Biomass burning contributes the largest fraction to total historical OP in Atlanta, followed by light-duty gasoline vehicles and heavy-duty diesel vehicles (43, 22 and 17%, respectively). Results find significant associations between estimated OP and emergency department visits related to congestive heart failure and asthma/wheezing attacks, supporting the hypothesis that PM2.5 health effects are, in part, due to oxidative stress and that OP is a useful indicator of PM2.5 health impacts. Finally, controlling PM2.5 sources with high OP, like biomass burning, may help prevent acute health effects.
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U2 - 10.1007/978-3-319-57645-9_79
DO - 10.1007/978-3-319-57645-9_79
M3 - Chapter
AN - SCOPUS:85060443588
T3 - Springer Proceedings in Complexity
SP - 503
EP - 508
BT - Springer Proceedings in Complexity
PB - Springer
ER -