Solving inverse scattering problems in biological samples by quantitative phase imaging

Taewoo Kim, Renjie Zhou, Lynford L. Goddard, Gabriel Popescu

Research output: Contribution to journalReview article

Abstract

Quantitative phase imaging (QPI), a method that precisely recovers the wavefront of an electromagnetic field scattered by a transparent, weakly scattering object, is a rapidly growing field of study. By solving the inverse scattering problem, the structure of the scattering object can be reconstructed from QPI data. In the past decade, 3D optical tomographic reconstruction methods based on QPI techniques to solve inverse scattering problems have made significant progress. In this review, we highlight a number of these advances and developments. In particular, we cover in depth Fourier transform light scattering (FTLS), optical diffraction tomography (ODT), and white-light diffraction tomography (WDT). Quantitative phase imaging (QPI) precisely recovers the wavefront of an electromagnetic field scattered by a transparent, weakly scattering object. In the past decade, 3D optical tomographic reconstruction methods based on QPI techniques to solve inverse scattering problems have made significant progress. This review highlights a number of advances and developments in QPI including Fourier transform light scattering (FTLS), optical diffraction tomography (ODT), and white-light diffraction tomography (WDT).

Original languageEnglish (US)
Pages (from-to)13-39
Number of pages27
JournalLaser and Photonics Reviews
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2016

Keywords

  • Interferometry
  • Label-free
  • Light scattering
  • Live cells
  • Microscopy
  • Phase retrieval
  • Quantitative phase imaging
  • Tissues

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics

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