Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities

Sungbong Kim, Boram Lee, Jonathan T Reeder, Seon Hee Seo, Sung-Uk Lee, Aurélie Hourlier-Fargette, Joonchul Shin, Yurina Sekine, Hyoyoung Jeong, Yong Suk Oh, Alexander J Aranyosi, Stephen P Lee, Jeffrey B Model, Geumbee Lee, Min-Ho Seo, Sung Soo Kwak, Seongbin Jo, Gyungmin Park, Sunghyun Han, Inkyu ParkHyo-Il Jung, Roozbeh Ghaffari, Jahyun Koo, Paul V Braun, John A Rogers

Research output: Contribution to journalArticlepeer-review

Abstract

Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.

Original languageEnglish (US)
JournalProceedings of the National Academy of Sciences of the United States of America
DOIs
StateE-pub ahead of print - Oct 26 2020

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