Social Stress Mobilizes Hematopoietic Stem Cells to Establish Persistent Splenic Myelopoiesis

Daniel B. McKim, Wenyuan Yin, Yufen Wang, Steve W. Cole, Jonathan P. Godbout, John F. Sheridan

Research output: Contribution to journalArticlepeer-review

Abstract

Psychosocial stress accelerates myelopoietic production of monocytes and neutrophils that contributes to a variety of health complications ranging from atherosclerosis to anxiety. Here, we show that social stress in mice mobilizes hematopoietic stem progenitor cells (HSPCs) from the bone marrow that enter circulation, engraft into the spleen, and establish a persistent extramedullary hematopoietic depot. These splenic progenitors actively proliferate and differentiate into multiple cell types, including monocytes, neutrophils, and erythrocytes. Splenic erythropoiesis partially abrogates stress-induced anemia. Repeated injection with isoprenaline induces progenitor mobilization to the spleen, identifying a key role for β-adrenergic signaling. Moreover, protracted splenic production of CD11b+ cells persists for at least 24 days after the cessation of social stress. Thus, chronic stress establishes a persistent extramedullary hematopoietic depot that can modify a wide range of chronic disease processes and alter homeostasis of the bi-directional regulatory axis between the nervous and immune systems. McKim et al. show that social stress enhances innate immune cell production in the bone marrow and mobilizes blood cell progenitors to the spleen, where they establish protracted ectopic production of innate immune cells. This represents a mechanism by which stress causes protracted changes in immunity and inflammation.

Original languageEnglish (US)
Pages (from-to)2552-2562.e3
JournalCell Reports
Volume25
Issue number9
DOIs
StatePublished - Nov 27 2018

Keywords

  • extramedullary hematopoiesis
  • hematopoiesis
  • hematopoietic stem cells
  • myelopoiesis
  • spleen
  • stress

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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