Social stress alters the severity and onset of the chronic phase of Theiler's virus infection

Robin R. Johnson; Thomas W. Prentice; Patrick Bridegam; Colin R. Young; Andrew J. Steelman; Thomas H. Welsh; C. Jane R. Welsh; Mary W. Meagher

doi:10.1016/j.jneuroim.2006.02.014

Social stress alters the severity and onset of the chronic phase of Theiler's virus infection

Robin R. Johnson, Thomas W. Prentice, Patrick Bridegam, Colin R. Young, Andrew J. Steelman, Thomas H. Welsh, C. Jane R. Welsh, Mary W. Meagher

Research output: Contribution to journal › Article › peer-review

Abstract

Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.

Original language	English (US)
Pages (from-to)	39-51
Number of pages	13
Journal	Journal of Neuroimmunology
Volume	175
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2006.02.014
State	Published - Jun 2006
Externally published	Yes

Keywords

IL-6
Multiple sclerosis
Neurodegeneration
Social stress
TMEV

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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10.1016/j.jneuroim.2006.02.014

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Social stress alters the severity and onset of the chronic phase of Theiler's virus infection. / Johnson, Robin R.; Prentice, Thomas W.; Bridegam, Patrick; Young, Colin R.; Steelman, Andrew J.; Welsh, Thomas H.; Welsh, C. Jane R.; Meagher, Mary W.

In: Journal of Neuroimmunology, Vol. 175, No. 1-2, 06.2006, p. 39-51.

Research output: Contribution to journal › Article › peer-review

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title = "Social stress alters the severity and onset of the chronic phase of Theiler's virus infection",

abstract = "Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.",

keywords = "IL-6, Multiple sclerosis, Neurodegeneration, Social stress, TMEV",

author = "Johnson, {Robin R.} and Prentice, {Thomas W.} and Patrick Bridegam and Young, {Colin R.} and Steelman, {Andrew J.} and Welsh, {Thomas H.} and Welsh, {C. Jane R.} and Meagher, {Mary W.}",

note = "Funding Information: We would like to thank Katie Hare, Marilyn Connor, E. Ashley Hardin, Jessica Harrison and Jordan Teraski for their help and support throughout this study. In addition, this research was supported by F31 NS504762 and NSF Fellowships to RRJ, NMSS RG3128 and NINDS RO1 NS39569 to CJRW and MWM. ",

year = "2006",

month = jun,

doi = "10.1016/j.jneuroim.2006.02.014",

language = "English (US)",

volume = "175",

pages = "39--51",

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AU - Johnson, Robin R.

AU - Prentice, Thomas W.

AU - Bridegam, Patrick

AU - Young, Colin R.

AU - Steelman, Andrew J.

AU - Welsh, Thomas H.

AU - Welsh, C. Jane R.

AU - Meagher, Mary W.

N1 - Funding Information: We would like to thank Katie Hare, Marilyn Connor, E. Ashley Hardin, Jessica Harrison and Jordan Teraski for their help and support throughout this study. In addition, this research was supported by F31 NS504762 and NSF Fellowships to RRJ, NMSS RG3128 and NINDS RO1 NS39569 to CJRW and MWM.

PY - 2006/6

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N2 - Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.

AB - Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.

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KW - Multiple sclerosis

KW - Neurodegeneration

KW - Social stress

KW - TMEV

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JO - Advances in Neuroimmunology

JF - Advances in Neuroimmunology

SN - 0165-5728

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ER -

Social stress alters the severity and onset of the chronic phase of Theiler's virus infection

Abstract

Keywords

ASJC Scopus subject areas

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