Social stress alters the severity and onset of the chronic phase of Theiler's virus infection

Robin R. Johnson, Thomas W. Prentice, Patrick Bridegam, Colin R. Young, Andrew J. Steelman, Thomas H. Welsh, C. Jane R. Welsh, Mary W. Meagher

Research output: Contribution to journalArticlepeer-review

Abstract

Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.

Original languageEnglish (US)
Pages (from-to)39-51
Number of pages13
JournalJournal of Neuroimmunology
Volume175
Issue number1-2
DOIs
StatePublished - Jun 2006
Externally publishedYes

Keywords

  • IL-6
  • Multiple sclerosis
  • Neurodegeneration
  • Social stress
  • TMEV

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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