Abstract
Social stress alters the acute phase of Theiler's virus infection (TMEV), a model of multiple sclerosis. Stress applied prior to infection had deleterious disease outcomes, while stress applied concurrent with infection was protective. The current study examined multiple behavioral (motor impairment, open field activity) and immunological measures (IL-6, antibodies to virus and myelin proteins) in both the acute and chronic phases of TMEV. It was found that stress applied prior to infection exacerbated disease outcomes, while concurrent application was protective in both disease phases.
Original language | English (US) |
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Pages (from-to) | 39-51 |
Number of pages | 13 |
Journal | Journal of Neuroimmunology |
Volume | 175 |
Issue number | 1-2 |
DOIs | |
State | Published - Jun 2006 |
Externally published | Yes |
Keywords
- IL-6
- Multiple sclerosis
- Neurodegeneration
- Social stress
- TMEV
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology