TY - JOUR
T1 - Social experience calibrates neural sensitivity to social feedback during adolescence
T2 - A functional connectivity approach
AU - Rudolph, Karen D.
AU - Davis, Megan M.
AU - Skymba, Haley V.
AU - Modi, Haina H.
AU - Telzer, Eva H.
N1 - Publisher Copyright:
© 2020
PY - 2021/2
Y1 - 2021/2
N2 - The adaptive calibration model suggests exposure to highly stressful or highly supportive early environments sensitizes the brain to later environmental input. We examined whether family and peer experiences predict neural sensitivity to social cues in 85 adolescent girls who completed a social feedback task during a functional brain scan and an interview assessing adversity. Whole-brain functional connectivity (FC) analyses revealed curvilinear associations between social experiences and FC between the ventral striatum and regions involved in emotion valuation, social cognition, and salience detection (e.g., insula, MPFC, dACC, dlPFC) during social reward processing, such that stronger FC was found at both very high and very low levels of adversity. Moreover, exposure to adversity predicted stronger FC between the amygdala and regions involved in salience detection, social cognition, and emotional memory (e.g., sgACC, precuneus, lingual gyrus, parahippocampal gyrus) during social threat processing. Analyses also revealed some evidence for blunted FC (VS-PCC for reward; amygdala-parahippocampal gyrus for threat) at very high and low levels of adversity. Overall, results suggest social experiences may play a critical role in shaping neural sensitivity to social feedback during adolescence. Future work will need to elucidate the implications of these patterns of neural function for the development of psychopathology.
AB - The adaptive calibration model suggests exposure to highly stressful or highly supportive early environments sensitizes the brain to later environmental input. We examined whether family and peer experiences predict neural sensitivity to social cues in 85 adolescent girls who completed a social feedback task during a functional brain scan and an interview assessing adversity. Whole-brain functional connectivity (FC) analyses revealed curvilinear associations between social experiences and FC between the ventral striatum and regions involved in emotion valuation, social cognition, and salience detection (e.g., insula, MPFC, dACC, dlPFC) during social reward processing, such that stronger FC was found at both very high and very low levels of adversity. Moreover, exposure to adversity predicted stronger FC between the amygdala and regions involved in salience detection, social cognition, and emotional memory (e.g., sgACC, precuneus, lingual gyrus, parahippocampal gyrus) during social threat processing. Analyses also revealed some evidence for blunted FC (VS-PCC for reward; amygdala-parahippocampal gyrus for threat) at very high and low levels of adversity. Overall, results suggest social experiences may play a critical role in shaping neural sensitivity to social feedback during adolescence. Future work will need to elucidate the implications of these patterns of neural function for the development of psychopathology.
KW - Adolescence
KW - Amygdala
KW - Family adversity
KW - Functional connectivity
KW - Peer adversity
KW - Ventral striatum
UR - http://www.scopus.com/inward/record.url?scp=85098198888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85098198888&partnerID=8YFLogxK
U2 - 10.1016/j.dcn.2020.100903
DO - 10.1016/j.dcn.2020.100903
M3 - Article
C2 - 33370666
AN - SCOPUS:85098198888
SN - 1878-9293
VL - 47
JO - Developmental Cognitive Neuroscience
JF - Developmental Cognitive Neuroscience
M1 - 100903
ER -