Smart "turn-on" magnetic resonance contrast agents based on aptamer-functionalized superparamagnetic iron oxide nanoparticles

Mehmet Veysel Yigit, Debapriya Mazumdar, Hee Kyung Kim, Jung Heon Lee, Boris Odintsov, Yi Lu

Research output: Contribution to journalArticlepeer-review

Abstract

(Figure Presented) Smart agents. A contrast agent was designed by combining target specific nucleic-acid aptamers against adenosine with superparamagnetic iron oxide nanoparticles. Target-induced disassembly of clustered nanoparticles in the presence of adenosine led to an increase in T2, which was seen as an increase in the brightness of the magnetic resonance image (see figure).

Original languageEnglish (US)
Pages (from-to)1675-1678
Number of pages4
JournalChemBioChem
Volume8
Issue number14
DOIs
StatePublished - Sep 24 2007

Keywords

  • Adenosine
  • Aptamers
  • Imaging agents
  • Magnetic resonance imaging
  • Nanostructures

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry, Genetics and Molecular Biology(all)

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