Small RNAs regulate primary and secondary metabolism in gram-negative bacteria

Maksym Bobrovskyy, Carin K. Vanderpool, Gregory R. Richards

Research output: Chapter in Book/Report/Conference proceedingChapter


A diverse palette of novel small regulatory RNAs (sRNAs) has been identified in bacteria in recent years, and many play important roles in regulating gene expression and adaptation to constantly changing physiological and metabolic needs. To date, more than a hundred sRNAs have been identified and characterized in gram-negative bacteria, with crucial and sometimes global regulatory functions that can easily rival protein regulators. The most studied and widely dispersed class of sRNAs in gram-negative bacteria act post-transcriptionally by base pairing to target mRNAs in order to effect positive or negative regulatory outcomes.

Original languageEnglish (US)
Title of host publicationMetabolism and Bacterial Pathogenesis
Number of pages36
ISBN (Electronic)9781683670926
ISBN (Print)9781555818869
StatePublished - Aug 4 2015


  • Amino acid metabolism
  • Amino sugar metabolism
  • Carbon catabolite repression
  • Quorum sensing
  • Small regulatory RNA

ASJC Scopus subject areas

  • Immunology and Microbiology(all)


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