TY - JOUR
T1 - Small RNAs regulate primary and secondary metabolism in gram-negative bacteria
AU - Bobrovskyy, Maksym
AU - Vanderpool, Carin K.
AU - Richards, Gregory R.
N1 - Publisher Copyright:
© 2014 American Society for Microbiology.
PY - 2015
Y1 - 2015
N2 - Over the last decade, small (often noncoding) RNA molecules have been discovered as important regulators influencing myriad aspects of bacterial physiology and virulence. In particular, small RNAs (sRNAs) have been implicated in control of both primary and secondary metabolic pathways in many bacterial species. This chapter describes characteristics of the major classes of sRNA regulators, and highlights what is known regarding their mechanisms of action. Specific examples of sRNAs that regulate metabolism in gram-negative bacteria are discussed, with a focus on those that regulate gene expression by base pairing with mRNA targets to control their translation and stability.
AB - Over the last decade, small (often noncoding) RNA molecules have been discovered as important regulators influencing myriad aspects of bacterial physiology and virulence. In particular, small RNAs (sRNAs) have been implicated in control of both primary and secondary metabolic pathways in many bacterial species. This chapter describes characteristics of the major classes of sRNA regulators, and highlights what is known regarding their mechanisms of action. Specific examples of sRNAs that regulate metabolism in gram-negative bacteria are discussed, with a focus on those that regulate gene expression by base pairing with mRNA targets to control their translation and stability.
UR - http://www.scopus.com/inward/record.url?scp=84949840792&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84949840792&partnerID=8YFLogxK
U2 - 10.1128/microbiolspec.MBP-0009-2014
DO - 10.1128/microbiolspec.MBP-0009-2014
M3 - Article
C2 - 26185078
AN - SCOPUS:84949840792
SN - 2165-0497
VL - 3
JO - Microbiology Spectrum
JF - Microbiology Spectrum
IS - 3
M1 - MBP-0009-2014
ER -