Small RNAs regulate primary and secondary metabolism in gram-negative bacteria

Maksym Bobrovskyy, Carin K. Vanderpool, Gregory R. Richards

Research output: Contribution to journalArticle


Over the last decade, small (often noncoding) RNA molecules have been discovered as important regulators influencing myriad aspects of bacterial physiology and virulence. In particular, small RNAs (sRNAs) have been implicated in control of both primary and secondary metabolic pathways in many bacterial species. This chapter describes characteristics of the major classes of sRNA regulators, and highlights what is known regarding their mechanisms of action. Specific examples of sRNAs that regulate metabolism in gram-negative bacteria are discussed, with a focus on those that regulate gene expression by base pairing with mRNA targets to control their translation and stability.

Original languageEnglish (US)
Article numberMBP-0009-2014
JournalMicrobiology Spectrum
Issue number3
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Physiology
  • Ecology
  • Immunology and Microbiology(all)
  • Genetics
  • Microbiology (medical)
  • Cell Biology
  • Infectious Diseases

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