Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co- glycolide) composite microparticles

Emily J. Pollauf, Kyekyoon Kevin Kim, Daniel W. Pack

Research output: Contribution to journalArticlepeer-review

Abstract

Addition of biodegradable polymer shells surrounding polymeric, drug-loaded microparticles offers the opportunity to control drug release rates. A novel fabrication method was used to produce microparticles with precise control of particle diameter and the thickness of the polymer shell. The effect of shell thickness on release of a model drug, piroxicam, has been clearly shown for 2- to 15-μm thick shells of poly(D,L-lactide) (PDLL) surrounding a poly(D,L-lactide-co-glycolide) (PLG) core and compared to pure PLG microspheres loaded with piroxicam. Furthermore, the core-shell microparticles are compared to microspheres containing blended polymers in the same mass ratios to demonstrate the importance of the core-shell morphology. Combining PDLL(PLG) microcapsules of different shell thicknesses allows nearly constant release rates to be attained for a period of 6 weeks.

Original languageEnglish (US)
Pages (from-to)2013-2022
Number of pages10
JournalJournal of Pharmaceutical Sciences
Volume94
Issue number9
DOIs
StatePublished - Sep 2005

Keywords

  • Controlled release
  • Microcapsule
  • Piroxicam

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science

Fingerprint Dive into the research topics of 'Small-molecule release from poly(D,L-lactide)/poly(D,L-lactide-co- glycolide) composite microparticles'. Together they form a unique fingerprint.

Cite this