A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 17 2009|
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry