Small molecule ligands for bulged RNA secondary structures

S. Todd Meyer, Paul J. Hergenrother

Research output: Contribution to journalArticlepeer-review


A class of wedge-shaped small molecules has been designed, synthesized, and shown to bind bulged RNA secondary structures. These minimally cationic ligands exhibit good affinity and selectivity for certain RNA bulges as demonstrated in a fluorescent intercalator displacement assay.

Original languageEnglish (US)
Pages (from-to)4052-4055
Number of pages4
JournalOrganic Letters
Issue number18
StatePublished - Sep 17 2009

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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