Small animal lung imaging with an in-line X-ray phase contrast benchtop system

A. B. Garson, S. Gunsten, H. Guan, S. Vasireddi, S. Brody, M. A. Anastasio

Research output: Chapter in Book/Report/Conference proceedingConference contribution


We present the results from a benchtop X-ray phase-contrast (XPC) method for lung imaging that represents a paradigm shift in the way small animal lung imaging is performed. In our method, information regarding airway microstructure that is encoded within speckle texture of a single XPC radiograph is decoded to spatially resolve changes in lung properties such as microstructure sizes, air volumes, and compliance, to name a few. Such functional information cannot be derived from conventional lung radiography or any other 2D imaging modality. By computing these images at different time points within a breathing cycle, dynamic functional imaging can be potentially achieved without the need for tomography.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2015
Subtitle of host publicationPhysics of Medical Imaging
EditorsChristoph Hoeschen, Despina Kontos, Christoph Hoeschen
ISBN (Electronic)9781628415025
StatePublished - 2015
Externally publishedYes
EventMedical Imaging 2015: Physics of Medical Imaging - Orlando, United States
Duration: Feb 22 2015Feb 25 2015

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


ConferenceMedical Imaging 2015: Physics of Medical Imaging
Country/TerritoryUnited States

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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