Sleep EEG changes after zolpidem in mice

Caroline Kopp, Uwe Rudolph, Irene Tobler

Research output: Contribution to journalArticlepeer-review

Abstract

Zolpidem is a widely used hypnotic that binds preferentially to α1GABAA receptors. We determined the role of these receptors in the effects of zolpidem on sleep in mutant mice carrying zolpidem-insensitive α1GABAA receptors and wild-type controls. Sleep was promoted by zolpidem in both genotypes. In wild-type mice non-REM sleep EEG power was markedly reduced in a broad frequency band >5 or 9 Hz after 5 and 10 mg/kg zolpidem, respectively. In mutants a power reduction appeared at the highest dose only, and was restricted to some low frequencies and the 9-10 Hz bin. We conclude that the effects of zolpidem on the sleep EEG in mice are distinct from the changes typically induced by benzodiazepines, and are primarily mediated by α1GABAA receptors.

Original languageEnglish (US)
Pages (from-to)2299-2302
Number of pages4
JournalNeuroreport
Volume15
Issue number14
DOIs
StatePublished - Oct 5 2004
Externally publishedYes

Keywords

  • Benzodiazepine
  • EEG
  • GABA receptor
  • Mice
  • Sleep
  • Slow-wave activity
  • Spectral analysis
  • Zolpidem
  • α(H101R)

ASJC Scopus subject areas

  • Neuroscience(all)

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