Abstract
Zolpidem is a widely used hypnotic that binds preferentially to α1GABAA receptors. We determined the role of these receptors in the effects of zolpidem on sleep in mutant mice carrying zolpidem-insensitive α1GABAA receptors and wild-type controls. Sleep was promoted by zolpidem in both genotypes. In wild-type mice non-REM sleep EEG power was markedly reduced in a broad frequency band >5 or 9 Hz after 5 and 10 mg/kg zolpidem, respectively. In mutants a power reduction appeared at the highest dose only, and was restricted to some low frequencies and the 9-10 Hz bin. We conclude that the effects of zolpidem on the sleep EEG in mice are distinct from the changes typically induced by benzodiazepines, and are primarily mediated by α1GABAA receptors.
Original language | English (US) |
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Pages (from-to) | 2299-2302 |
Number of pages | 4 |
Journal | Neuroreport |
Volume | 15 |
Issue number | 14 |
DOIs | |
State | Published - Oct 5 2004 |
Externally published | Yes |
Keywords
- Benzodiazepine
- EEG
- GABA receptor
- Mice
- Sleep
- Slow-wave activity
- Spectral analysis
- Zolpidem
- α(H101R)
ASJC Scopus subject areas
- General Neuroscience