Slaved diffusion in phospholipid bilayers

Liangfang Zhang, Steve Granick

Research output: Contribution to journalArticlepeer-review


The translational diffusion of phospholipids in supported fluid bilayers splits into two populations when polyelectrolytes adsorb at incomplete surface coverage. Spatially resolved measurements using fluorescence correlation spectroscopy show that a slow mode, whose magnitude scales inversely with the degree of polymerization of the adsorbate, coexists with a fast mode characteristic of naked lipid diffusion. Inner and outer leaflets of the bilayer are affected nearly equally. Mobility may vary from spot to spot on the membrane surface, despite the lipid composition being the same. This work offers a mechanism to explain how nanosized domains with reduced mobility arise in lipid membranes.

Original languageEnglish (US)
Pages (from-to)9118-9121
Number of pages4
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number26
StatePublished - Jun 28 2005
Externally publishedYes


  • Adsorption
  • Fluorescence correlation
  • Mobility

ASJC Scopus subject areas

  • Genetics
  • General


Dive into the research topics of 'Slaved diffusion in phospholipid bilayers'. Together they form a unique fingerprint.

Cite this